Ati: “Ibi byagezweho ahanini byunguka udushya mu ikoranabuhanga, imiyoborere isanzwe n'umusaruro w'icyatsi.”Zhang Ge yagize ati: “Bitewe n'imbaraga za Deebio zidatezuka ku ireme ryiza, ibicuruzwa bya bio-enzyme API bifite ibyiza nk'ibikorwa byinshi, isuku ihanitse kandi bihamye bityo bikaba bizwi cyane n'abafatanyabikorwa.”

Kubikora Byiza

Bio-enzymes ni poroteyine zifite imikorere ya catalitiki, itandukanye nizindi poroteyine kuko zifite ikigo gikora.API ya bio-enzymes iboneka mugutandukanya, gukuramo no kweza ibinyabuzima.

Ati: “Bio-enzyme API ni inganda zifite ishoramari rinini, inyungu nke kandi bifite tekiniki nyinshi.Ingano yinganda ni nto.Kandi hariho amasosiyete make abigiramo uruhare. ”Nk’uko Zhang Ge abitangaza ngo ibyago byinshi bya tekiniki biterwa nigikorwa cya enzymes bigatuma inzira yo kweza igorana.Kurugero, niba inzira itagenzuwe neza, igicuruzwa gishobora kutagira ibikorwa, hanyuma kigatakaza agaciro kacyo.

Bio-enzyme API nimwe mubikoresho fatizo bya bio-farumasi.Hamwe n'uburozi buke n'ingaruka, bio-farumasi yibasiwe cyane no kuvura indwara zimwe na zimwe kandi byoroshye kwakirwa numubiri wumuntu.Ifite ingaruka zidasanzwe zo kuvura diyabete, indwara z'umutima n'imitsi, ibibyimba n'indwara za virusi.

Ati: “Filozofiya yanjye ihamye ni uko igihe cyose nkora ibyo abandi badakora, mbikora neza.”Zhang Ge yizera ko impamvu yashinze imizi mu nganda za bio-enzyme ari imyaka 20 akunda bivuye ku mutima.Mu 1990, nyuma yo guhabwa impamyabumenyi muri kaminuza ya Sichuan (Yahoze muri kaminuza y’ubumenyi n’ikoranabuhanga ya Chengdu) yiga ibijyanye n’ibinyabuzima, Zhang Ge yakoraga nk'umutekinisiye, nyuma aba umuyobozi wa laboratoire mu ruganda rwa farumasi rwa Deyang.Nyuma yimyaka itanu, kubera kuvugurura uruganda, yatangiye ubucuruzi.

Ati: “Muri icyo gihe, uruganda rukora ibinyabuzima rugiye guhinduka uruganda rukora imiti.Nagiye mu ruganda kureba, mbona urubyiruko ruto ruvugurura amahugurwa mato ashaje.Mu maso habo huzuye amazi n'ibyondo.Muri bo harimo Zhang Ge. ”Zhong Guangde wahoze ari Umuyobozi wungirije w'ikigo gishinzwe ubuvuzi mu Ntara ya Sichuan, yibuka n'amarangamutima ati: “Zhang Ge aracyari umusore ukora ibintu bifatika mu maso yanjye.”

Ukuboza 1994, Zhang Ge yashinze Sichuan Deyang Biochemical Products Co., Ltd. Akimara gushingwa, yenda guhomba.

Ati: “Mu ntangiriro ya za 90, ubusanzwe ubumenyi bw’inganda za Bio-enzyme mu Bushinwa ntabwo bwari bukomeye, kandi ntabwo twasobanukiwe neza imisemburo yari ikiri nto kubera ko ubumenyi bw’imisemburo ihagije.”Nk’uko Zhang Ge abitangaza ngo muri Werurwe 1995, ikigo gishya cyitwa Deyang Biochemical Products Co., Ltd. cyabonye itegeko ryambere rya kallidinogenase ya peteroli yoherezwa ku isoko ry’Ubuyapani.Nyamara, ibicuruzwa byanze kubera itandukaniro rya miligarama nkeya mubinure.Ati: “Niba undi muburanyi asabye indishyi, isosiyete yari guhomba, kandi amafaranga y'indishyi yari afite icyogajuru kuri icyo gihe.Ku bw'amahirwe, binyuze mu guhuza ibikorwa, undi muburanyi ntiyadusabye kwishyura ariko reka twongere dutange ibicuruzwa ”, Zhang Ge.

Ubunararibonye bwigishije Zhang Ge, wari utangiye ubucuruzi, isomo ryingenzi kandi bituma amenya ko ubuziranenge bwibicuruzwa ari ubuzima bwikigo.Mu myaka 27 iri imbere yiterambere, isosiyete yamye yubahiriza ubuziranenge bukomeye.Hashingiwe kumyaka yubushakashatsi bwibanze, Deebio yahoraga atezimbere ikoranabuhanga ryayo, bityo hashyirwaho uburyo bwuzuye bwo kurinda ibikorwa bya enzyme, ibikorwa bidasenya hamwe nubuhanga bwo kweza neza kugirango habeho ibikorwa byinshi, isuku ryinshi hamwe n’umutekano muke wibicuruzwa bya Bio-enzyme API.

Gutanga Nta mbaraga zo gushora mu guhanga udushya

“Inganda za bio-enzyme API zigaragazwa na bike no gutandukana.Hatabayeho guhanga udushya, ibicuruzwa kimwe cyangwa bibiri ntibishobora gutera inkunga sosiyete kwiteza imbere.Deebio ifite igicuruzwa kimwe kuva yashingwa.Ariko uyu munsi hari APIs zirenga icumi za bio-enzyme, zidashobora gutandukanywa n’ishoramari rihoraho mu ikoranabuhanga. ”Zhang Ge ati.

Trypsin-Chymotrypsin ni enzyme ya proteolyique yatandukanijwe kandi isukurwa na pancreas.Nibimwe mubicuruzwa byingenzi bya Deebio.R&D yiki gicuruzwa yungukiye mu bufatanye n’inganda-kaminuza-ubushakashatsi.Mu 1963, Qi Zhengwu, umushakashatsi mu kigo cya Shanghai Institute of Physiology and Biochemistry of the Academy of Science of China, yakoresheje recrystallisation kugira ngo akuremo kristu ivanze ya chymotrypsin na trypsin ivuye mu mitsi yitwa pancreas, yitwaga trypsin-chymotrypsin.Iyi misemburo yari imaze imyaka irenga 30 itunganijwe.Zhang Ge yabonye amahirwe muri yo.Yakomeje agira ati: “Mu 1997, twakoranye n'itsinda ry'ubushakashatsi bw'abashakashatsi Qi Zhengwu kugira ngo tumenye inganda za trypsin-chymotrypsin kandi tugera ku nyungu nziza mu bukungu n'imibereho myiza.Mu gihe cyiza, toni zirenga 20 ku mwaka z’ibicuruzwa byoherejwe mu Buhinde. ”Ku bwa Zhang Ge, umuhanga mu bya Qi Zhengwu yagize ati: "Igitangaje ni uko ibicuruzwa byanjye byakozwe mu nganda no mu midugudu no mu midugudu. ′

Nyuma yo kuryoherwa no guhanga udushya mu ikoranabuhanga, Deebio yarushijeho kongera ishoramari mu ikoranabuhanga, anateza imbere ubufatanye n’inganda n’ubushakashatsi n’ubushakashatsi na kaminuza ya Tsinghua, Ishuri Rikuru ry’Ubushinwa, Kaminuza ya Sichuan, Kaminuza y’imiti y’Ubushinwa n’ibindi bigo by’amashuri makuru n’ibigo by’ubushakashatsi. , gufatanya kubaka laboratoire, guhora tunoza ubushakashatsi bwubumenyi nubushobozi bwo guhanga udushya no kubaka umusaruro hamwe nitsinda R&D rifite ubushobozi bwo guhindura ikoranabuhanga ryagiye rikurikirana tekinoroji 15 yemewe.

Mu rwego rwo kurushaho kunoza ubuziranenge bw’ibicuruzwa, mu 2003, Deebio yafatanyije n’umufatanyabikorwa w’umudage ufite ikoranabuhanga rigezweho ndetse n’ubushobozi bwo kuyobora mu gushinga umushinga uhuriweho witwa Deyang Sinozyme Pharmaceutical Co., Ltd. “Muri uwo mwaka, twashoye miliyoni zisaga 20 kubaka uruganda rushya, hamwe nibikoresho byo kubyaza umusaruro hamwe nibikoresho byo hejuru kwisi.Muri icyo gihe kimwe, uruganda rushobora kubakwa mu Bushinwa kuri miliyoni 5.Amafaranga yo kubaka Sinozyme angana n'ay'inganda 4. ”Nk’uko Zhang Ge abitangaza ngo umufatanyabikorwa w’Ubudage yasuye iyi sosiyete kugira ngo atange ubuyobozi mu minsi icumi buri kwezi.Hamwe nogutangiza uburyo bwiza bwo gucunga neza sisitemu, ubushobozi bwa sisitemu yo gucunga neza Sinozyme yazamuwe kurwego mpuzamahanga.

Muri 2005, Sinozyme ibaye sosiyete ya mbere yubushinwa pancreatin yabonye ibyemezo bya EU-GMP;muri 2011, hashyizweho Sichuan Deebio Pharmaceutical Co., Ltd.muri 2012, Deebio yabonye icyemezo cya CN-GMP;muri Mutarama 2021, Deebio (Chengdu) Bio-Technology Co., Ltd yashinzwe muri R&D, gukora no gukoresha imiti irangiye kandi itegura enzyme ya biotechnologiya.

Ati: “Ntekereza ko ibigo bigomba kugira ubushake bwo gushora imari mu guhanga udushya.Deebio yubatse uruganda rushya buri myaka 7 kugeza 8.Muri iyi myaka, inyungu nyinshi zashowe mubikorwa byo kubaka imishinga, guhindura ibikoresho byo gutunganya no kumenyekanisha impano.Abanyamigabane n'abayobozi babona inyungu nke. ”Zhang Ge, umaze kuba injeniyeri, yumva neza akamaro ko gushora ikoranabuhanga.Yakomeje umuvuduko wo guhanga udushya, anashyira ku rutonde ibintu bigomba gukorwa: Amahugurwa mashya ya GMP ya Deebio yubatswe akurikije amahame ya FDA yatangiye umwaka ushize bikaba biteganijwe ko azarangira mu mpera za Gicurasi akazinjira mu igeragezwa;Deebio (Chengdu) Bio-Technology Co., Ltd., iherereye i Wenjiang, muri Chengdu, yatangiye kubaka ku mugaragaro ku ya 26 Mata bikaba biteganijwe ko izatangira gukoreshwa ku mugaragaro mu Kwakira.

“Umusaruro w'icyatsi nicyo nishimira cyane”

Umwanda wa API wahoze uhangayikishijwe na societe, kandi kurengera ibidukikije byahindutse impagarara nyinshi zerekana ubuzima bwimishinga.Gukurikiza umusaruro wicyatsi nicyo Zhang Ge yishimira cyane.

Ati: “Mu iterambere ryambere ry’isosiyete, ntitwitaye cyane ku bidukikije.Ariko rero, igihe igihugu cyashyiragaho ibisabwa byo kurengera ibidukikije, twatangiye kumenya akamaro kacyo. ”Ku bwa Zhang Ge, mu myaka icumi ishize, Deebio yabyitayeho cyane, aharanira kugera ku majyambere arambye.

Byari ibintu byateye impinduka.Yakomeje agira ati: “Mu nama hashize imyaka myinshi, abayobozi b'ikigo cyacu bateganyaga ibicuruzwa bikenera imiti igabanya ubukana.Imwe mu miti y’imiti ntishobora kwangirika kandi, iyo amazi y’amazi asohotse mu ruzi, bishobora gutera ubumuga bw’abana.Sinatindiganyije kuvuga ngo oya kuri iki gicuruzwa. ”Avuga ibyabaye, Zhang Ge yagize amarangamutima cyane, ati: "Umujyi mvukamo uri hafi y'umugezi wa Tuojiang, uri ku birometero birenga 200 uvuye i Guanghan, muri Sichuan.Kandi uruzi kuruhande rwuruganda rwacu rutemba mumugezi wa Tuojiang.Gusohora imyanda itaziguye nicyaha cyibisekuruza bizaza.Ntabwo rero nzakora ikintu nk'icyo. ”

Kuva icyo gihe, Deebio yavuze ko igihe cyose umusaruro uzaba urimo ibikoresho fatizo bya chimique bifite ubumara kandi byangiza cyangwa ibikoresho bifasha bidashobora gutunganywa mugutezimbere ibicuruzwa bishya, iterambere ntirizemerwa, kandi ryashimangiye gushora imari mukurengera ibidukikije hejuru yimyaka icumi.

Uyu munsi, Deebio yubatse ikigo cyo gutunganya imyanda yubusitani bwubusitani bufite ubushobozi bwo gutunganya buri munsi bwa 1.000m³, amazi y’imyanda asohoka nyuma yo kugera ku gipimo.Ati: “Ubu bushobozi burahagije kugirango dukoreshe imyaka icumi.Kandi ubusitani bwubatswe byumwihariko hejuru yikigo gitunganya amazi.Amazi yatunganijwe arashobora gukoreshwa mu kuzamura amafi n'indabyo z'amazi, ”ibi bikaba byavuzwe na Zhang Ge.

Byongeye kandi, imyanda irashobora gutunganywa no gutera hamwe nubundi buryo, kandi biyogazi irashobora gukoreshwa mu gushyushya ibyuka nyuma yo kwangirika no kubura umwuma, bityo bikabika 800m³ ya gaze gasanzwe buri munsi.Kubintu bikomeye byakozwe, hariho amahugurwa yihariye yo gutunganya.Imyanda ya poroteyine ihinduka ifumbire mvaruganda mu minota 4 ikoresheje akuma hanyuma ikoherezwa mu gihingwa cy’ifumbire mvaruganda.

Zhang Ge yagize amarangamutima agira ati: “Ubu ubuso bwose bwibimera ntibutanga impumuro yihariye, kandi amazi yimyanda hamwe n’imyanda ihumanya neza.Ibi ndabyishimiye kuruta umusaruro wibicuruzwa, nicyo kintu nagezeho mpa agaciro cyane. ”

Ku bijyanye n'iterambere ry'ejo hazaza, Zhang Ge yuzuye ikizere, “Iterambere ry'inganda risaba iterambere rihoraho.Iterambere ryiza cyane ryinganda za bio-enzyme API ntabwo risobanura gusa umusaruro wibicuruzwa byujuje ubuziranenge, ahubwo binagira ikoranabuhanga rigezweho, imikorere inoze, ibisabwa mu micungire ihanitse, hamwe nuburyo bwo kubungabunga ibidukikije.Deebio azafata ubuyobozi bw'iterambere ry’inganda mu rwego rwo hejuru nk'inshingano zayo, kandi akorera abantu bose babikuye ku mutima ubuzima bwabo mu nzira y'iterambere rishya. ”