Ati: “Ibi byagezweho ahanini byungukirwa no guhanga udushya mu ikoranabuhanga, imiyoborere isanzwe n'umusaruro w'icyatsi.”Zhang Ge yagize ati: “Bitewe n'imbaraga za Deebio zidatezuka ku rwego rwo hejuru, ibicuruzwa bio-enzyme API bifite ibyiza nk'ibikorwa byinshi, isuku nyinshi ndetse n'umutekano muke bityo bikaba bizwi cyane n'abafatanyabikorwa.”

Kubikora Byiza

Bio-enzymes ni poroteyine zifite imikorere ya catalitiki, itandukanye nizindi poroteyine kuko zifite ikigo gikora.API ya bio-enzymes iboneka mugutandukana, gukuramo no kweza ibinyabuzima.

Ati: “Bio-enzyme API ni inganda zifite ishoramari rinini, inyungu nke ndetse n’impanuka nyinshi za tekiniki.Ingano yinganda ni nto.Kandi hariho amasosiyete make abigiramo uruhare. ”Nk’uko Zhang Ge abitangaza ngo ibyago byinshi bya tekiniki biterwa n'ibikorwa bya enzymes bituma inzira yo kweza igorana.Kurugero, niba inzira itagenzuwe neza, ibicuruzwa birashobora kutagira ibikorwa, hanyuma bigatakaza agaciro kacyo kivura.

Bio-enzyme API nimwe mubikoresho fatizo bya bio-farumasi.Hamwe n'uburozi buke n'ingaruka, bio-farumasi yibasiwe cyane no kuvura indwara zimwe na zimwe kandi byoroshye kwinjizwa numubiri wumuntu.Ifite ingaruka zidasanzwe zo kuvura diyabete, indwara z'umutima n'imitsi, ibibyimba n'indwara za virusi.

Ati: “Filozofiya yanjye ihamye ni uko igihe cyose nkora ibyo abandi badakora, mbikora neza.”Zhang Ge yemera ko impamvu yashinze imizi mu nganda za bio-enzyme mu myaka irenga 20 ari urukundo ruvuye ku mutima akunda imisemburo.Mu 1990, nyuma yo guhabwa impamyabumenyi muri kaminuza ya Sichuan (Yahoze ari kaminuza y’ubumenyi n’ikoranabuhanga ya Chengdu) yize ibijyanye n’ibinyabuzima, Zhang Ge yakoraga nk'umutekinisiye, nyuma aba umuyobozi wa laboratoire mu ruganda rukora imiti rwa Deyang.Nyuma yimyaka itanu, kubera kuvugurura uruganda, yatangiye ubucuruzi.

Ati: “Muri icyo gihe, uruganda rukora ibinyabuzima rwari rugiye guhinduka uruganda rukora imiti.Nagiye mu ruganda kureba, mbona urubyiruko ruto ruvugurura amahugurwa mato ashaje.Mu maso habo huzuye amazi n'ibyondo.Muri bo harimo Zhang Ge. ”Zhong Guangde wahoze ari Umuyobozi wungirije w'ikigo gishinzwe ubuvuzi mu Ntara ya Sichuan, yibuka n'amarangamutima ati: “Zhang Ge aracyari umusore ukora ibintu bifatika mu maso yanjye.”

Ukuboza 1994, Zhang Ge yashinze Sichuan Deyang Biochemical Products Co., Ltd. Akimara gushingwa, yenda guhomba.

Ati: “Mu ntangiriro ya za 90, ubumenyi bw’inganda mu nganda za Bio-enzyme mu Bushinwa muri rusange ntabwo bwari bukomeye, kandi ntabwo twasobanukiwe imisemburo yari igarukira gusa ku kumenya ko ibikorwa byiza bya enzyme bihagije.”Nk’uko Zhang Ge abitangaza ngo muri Werurwe 1995, ikigo gishya cyitwa Deyang Biochemical Products Co., Ltd. cyabonye itegeko ryambere rya kallidinogenase ya peteroli yoherezwa ku isoko ry’Ubuyapani.Nyamara, ibicuruzwa byanze kubera itandukaniro rya miligarama nkeya mubinure.Ati: “Niba undi muburanyi asabye indishyi, isosiyete yari guhomba, kandi umubare w'indishyi wari mu bumenyi bw'ikirere muri icyo gihe.Ku bw'amahirwe, binyuze mu guhuza ibikorwa, undi muburanyi ntabwo yadusabye kwishyura ariko reka twongere dutange ibicuruzwa ”, Zhang Ge.

Ubunararibonye bwigishije Zhang Ge, wari utangiye ubucuruzi, isomo ryingenzi kandi bituma amenya ko ubuziranenge bwibicuruzwa aribwo buzima bwikigo.Mu myaka 27 yakurikiyeho yiterambere, isosiyete yamye yubahiriza ubuziranenge bukomeye.Hashingiwe ku myaka y’ubushakashatsi bwibanze, Deebio yahoraga atezimbere ikoranabuhanga ryayo, bityo hashyirwaho uburyo bwuzuye bwo kurinda ibikorwa bya enzyme, ibikorwa bidasenya ndetse nubuhanga bwo kweza neza kugirango habeho ibikorwa byinshi, isuku ryinshi n’umutekano muke wibicuruzwa bya Bio-enzyme API.

Kwirinda Nta mbaraga zo gushora mu guhanga udushya

“Inganda za bio-enzyme API zigaragazwa n’amafaranga make no gutandukana.Hatabayeho guhanga udushya, ibicuruzwa kimwe cyangwa bibiri ntibishobora gutera inkunga sosiyete gutera imbere.Deebio ifite ibicuruzwa kimwe kuva yashingwa.Ariko uyu munsi hari APIs zirenga icumi za bio-enzyme, zidashobora gutandukana n’ishoramari dukomeje mu ikoranabuhanga. ”Zhang Ge ati.

Trypsin-Chymotrypsin ni enzyme ya proteolyique yatandukanijwe kandi isukurwa na pancreas.Nibimwe mubicuruzwa byingenzi bya Deebio.R&D yiki gicuruzwa yungukiye mu bufatanye n’inganda-kaminuza n’ubushakashatsi.Mu 1963, Qi Zhengwu, umushakashatsi mu kigo cya Shanghai Institute of Physiology and Biochemistry of the Academy of Science of China, yakoresheje recrystallisation kugira ngo akuremo kristu ivanze ya chymotrypsin na trypsin ivuye mu mitsi yitwa pancreas, yitwaga trypsin-chymotrypsin.Iyi misemburo ntabwo yari imaze imyaka irenga 30 mu nganda.Zhang Ge yabonye amahirwe arimo.Yakomeje agira ati: “Mu 1997, twafatanije n'itsinda ry'ubushakashatsi bw'abashakashatsi Qi Zhengwu kugira ngo tumenye inganda za trypsin-chymotrypsin kandi tugera ku nyungu nziza mu bukungu n'imibereho myiza.Mu gihe cyiza, toni zirenga 20 ku mwaka z’ibicuruzwa byoherejwe mu Buhinde. ”Ku bwa Zhang Ge, umwarimu Qi Zhengwu yerekanye ati: "Igitangaje ni uko ibicuruzwa byanjye byakozwe mu nganda n’imishinga yo mu mijyi no mu midugudu. ′

Nyuma yo kuryoherwa no guhanga udushya mu ikoranabuhanga, Deebio yarushijeho kongera ishoramari mu ikoranabuhanga, anatezimbere ubufatanye bw’inganda-kaminuza n’ubushakashatsi na kaminuza ya Tsinghua, Ishuri Rikuru ry’Ubushinwa, Kaminuza ya Sichuan, Kaminuza y’imiti y’Ubushinwa n’ibindi bigo by’amashuri makuru n’ibigo by’ubushakashatsi. , gufatanya kubaka laboratoire, gukomeza kunoza ubushakashatsi bwubumenyi nubushobozi bwo guhanga udushya no kubaka itsinda ryakozwe na R&D hamwe nubushobozi buhanitse bwo guhindura ikoranabuhanga ryagiye rikurikirana tekinoroji 15 yemewe.

Mu rwego rwo kurushaho kunoza ireme ry'ibicuruzwa, mu 2003, Deebio yafatanyije n’umufatanyabikorwa w’Ubudage ufite ikoranabuhanga n’ubuhanga buhanitse mu gushinga umushinga uhuriweho witwa Deyang Sinozyme Pharmaceutical Co., Ltd. “Muri uwo mwaka, twashoye miliyoni zisaga 20 kubaka uruganda rushya, hamwe nibikoresho byo kubyaza umusaruro hamwe nibikoresho byo hejuru kwisi.Muri icyo gihe kimwe, uruganda rushobora kubakwa mu Bushinwa kuri miliyoni 5.Amafaranga yo kubaka Sinozyme angana n'ay'inganda 4. ”Nk’uko Zhang Ge abitangaza ngo umufatanyabikorwa w’Ubudage yasuye iyi sosiyete kugira ngo atange ubuyobozi mu minsi icumi buri kwezi.Hamwe nogutangiza uburyo bwiza bwo gucunga neza sisitemu, ubushobozi bwa Sinozyme bwo gucunga neza sisitemu yazamuwe ku rwego mpuzamahanga.

Mu 2005, Sinozyme abaye sosiyete ya mbere y’Abashinwa pancreatin yabonye ibyemezo bya EU-GMP;mu 2011, hashyizweho Sichuan Deebio Pharmaceutical Co., Ltd.muri 2012, Deebio yabonye icyemezo cya CN-GMP;muri Mutarama 2021, Deebio (Chengdu) Bio-Technology Co., Ltd yashinzwe mu rwego rwa R&D, gukora no gukoresha imiti yo mu rwego rwo hejuru yarangije no gutegura enzyme ya biotechnologiya.

Ati: “Ntekereza ko ibigo bigomba kugira ubushake bwo gushora imari mu guhanga ikoranabuhanga.Deebio yubatse uruganda rushya buri myaka 7 kugeza 8.Muri iyi myaka, inyungu nyinshi zashowe mu kubaka imishinga, guhindura ibikoresho by’umusaruro no kumenyekanisha impano.Abanyamigabane n'abayobozi babona inyungu nke. ”Zhang Ge, wigeze kuba injeniyeri, yumva neza akamaro ko gushora ikoranabuhanga.Yakomeje umuvuduko wo guhanga udushya, anashyira ku rutonde ibintu byinshi byo gukora: Amahugurwa mashya ya GMP ya Deebio yubatswe hakurikijwe amahame ya FDA yatangiye umwaka ushize bikaba biteganijwe ko azarangira mu mpera za Gicurasi akazinjira mu bicuruzwa;Deebio (Chengdu) Bio-Technology Co., Ltd., i Wenjiang, Chengdu, yatangiye kubaka ku mugaragaro ku ya 26 Mata bikaba biteganijwe ko izatangira gukoreshwa mu Kwakira.

“Umusaruro w'icyatsi nicyo nishimira cyane”

Umwanda wa API wahoraga uhangayikishijwe na societe, kandi kurengera ibidukikije byabaye impagarara nyinshi zerekana ubuzima bwimishinga.Gukurikiza umusaruro wicyatsi nicyo Zhang Ge yishimira cyane.

Ati: “Mu iterambere rya mbere ry’isosiyete, ntitwitaye cyane ku bibazo by’ibidukikije.Ariko rero, ubwo igihugu cyashyiraga imbere ibisabwa byo kurengera ibidukikije, twatangiye kumenya akamaro kacyo. ”Ku bwa Zhang Ge, mu myaka icumi ishize, Deebio yabyitayeho cyane, aharanira kugera ku majyambere arambye.

Byari ibintu byateye impinduka.Yakomeje agira ati: “Mu nama hashize imyaka myinshi, abayobozi b'ikigo cyacu bateganyaga ibicuruzwa byari bikeneye imiti igabanya ubukana.Imwe mu miti y’imiti ntishobora kwangirika kandi, niba amazi y’amazi asohotse mu ruzi, bishobora gutera ubumuga bw’abana.Sinatindiganyije kuvuga ngo oya kuri iki gicuruzwa. ”Avuga ibyabaye, Zhang Ge yagize amarangamutima cyane, ati: "Umujyi wanjye w'amavuko uri hafi y'umugezi wa Tuojiang, uri ku birometero birenga 200 uvuye i Guanghan, muri Sichuan.Kandi uruzi kuruhande rwuruganda rwacu rutemba mumugezi wa Tuojiang.Gusohora imyanda itaziguye nicyaha cyibisekuruza bizaza.Ntabwo rero nzakora ikintu nk'icyo. ”

Kuva icyo gihe, Deebio yemeje ko igihe cyose umusaruro uzaba urimo ibikoresho fatizo by’ubumara byangiza kandi byangiza cyangwa ibikoresho bifasha bidashobora gutunganywa mu iterambere ry’ibicuruzwa bishya, iterambere ntirizemerwa, kandi ryashimangiye gushora imari mu kurengera ibidukikije imyaka irenga icumi.

Uyu munsi, Deebio yubatse ikigo gitunganya amazi y’imyanda y’ubusitani ifite ubushobozi bwo gutunganya buri munsi ingana na 1.000m³, amazi y’imyanda asohoka nyuma yo kugera ku gipimo.Ati: “Ubu bushobozi burahagije kugira ngo dukoreshe imyaka icumi.Kandi ubusitani bwubatswe byumwihariko hejuru yikigo gitunganya amazi.Amazi yatunganijwe arashobora gukoreshwa mu kuzamura amafi n'indabyo z'amazi, ”ibi bikaba byavuzwe na Zhang Ge.

Byongeye kandi, imyanda irashobora gutunganywa no gutera hamwe nubundi buryo, kandi biyogazi irashobora gukoreshwa mu gushyushya ibyuka nyuma yo kwangirika no kubura umwuma, bityo bikabika 800m³ ya gaze gasanzwe buri munsi.Kubintu bikomeye byakozwe, hari amahugurwa yihariye yo gutunganya.Imyanda ya poroteyine ihinduka ifumbire mvaruganda mu minota 4 ikoresheje icyuma ikoherezwa mu gihingwa cy’ifumbire mvaruganda.

Zhang Ge yagize amarangamutima agira ati: “Ubu agace k’ibimera ntigatanga impumuro yihariye, kandi amazi y’imyanda n’ibyuka bihumanya bigenzurwa neza.Nishimiye ibi kuruta umusaruro w’ibicuruzwa, ibyo bikaba aribyo nagezeho mpa agaciro cyane. ”

Ku bijyanye n'iterambere ry'ejo hazaza, Zhang Ge yuzuye icyizere, “Iterambere ry'inganda risaba iterambere rihoraho.Iterambere ryiza cyane ryinganda za bio-enzyme API ntabwo risobanura gusa umusaruro wibicuruzwa byujuje ubuziranenge gusa, ahubwo binagira ikoranabuhanga ryateye imbere, imikorere inoze, ibisabwa mu micungire ihanitse, nuburyo bwo kubungabunga ibidukikije.Deebio azafata ubuyobozi bw'iterambere ry’inganda mu rwego rwo hejuru nk'inshingano zayo, kandi azakorera abantu bose babikuye ku mutima ubuzima bwabo mu nzira y'iterambere rishya. ”